BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL*) IV. DEGRADATION OF BENADRYL BY TISSUE ENZYMESf
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چکیده
The excretion of unchanged Benadryl accounts for only a small portion of the total administered dose in man (1, 2). Indirect evidence for the presence of degradation products in tissues and urine was obtained with Benadryl labeled with radioactive carbon (3). The experiments reported here show that degradation is produced by tissue enzymes, resulting in a loss of the basic properties of Benadryl as measured by the methyl orange technique (4).
منابع مشابه
BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL*) II. DISTRIBUTION IN TISSUES AND URINARY EXCRETIONt
Benadryl has been used extensively as an antihistamine agent, but little is known concerning its mode of action or metabolic fate. It is rapidly absorbed, as shown by earlier blood level studies (l-3) and the fact that clinical effects are observed in less than an hour (4). This paper presents observations on the distribution of Benadryl in the rat, chosen for its resistance to the action of hi...
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